Non-steroidal anti-inflammatory drugs (NSAIDs)
NSAIDs
🟡 Several human studies point the same way, with a plausible biological mechanism, but the evidence is not yet conclusive.
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In brief
NSAIDs and fertility: this page reviews Non-steroidal anti-inflammatory drugs (NSAIDs) (NSAIDs) — documented mechanism, everyday exposure situations and possible alternatives. Level of evidence: Probable.
- Where it's found
- Ibuprofen, ketoprofen, high-dose aspirin, often self-medicated.
- Suspected mechanism
- Inhibition of prostaglandins, which are involved in ovulation and implantation; prolonged, high-dose use is associated with anovulatory cycles.
- Suggested alternative
- Reserve NSAIDs for short episodes and ask a pharmacist for advice in case of regular use.
- Source
- ANSM (French medicines agency), NSAID warnings; studies on anovulation.
Frequently asked questions
Non-steroidal anti-inflammatory drugs (NSAIDs): how is it linked to infertility?
Inhibition of prostaglandins, which are involved in ovulation and implantation; prolonged, high-dose use is associated with anovulatory cycles.
Where is Non-steroidal anti-inflammatory drugs (NSAIDs) found in everyday life?
Ibuprofen, ketoprofen, high-dose aspirin, often self-medicated.
How can exposure to Non-steroidal anti-inflammatory drugs (NSAIDs) be reduced?
Reserve NSAIDs for short episodes and ask a pharmacist for advice in case of regular use.
What is the level of evidence for Non-steroidal anti-inflammatory drugs (NSAIDs)?
Probable. Several human studies point the same way, with a plausible biological mechanism, but the evidence is not yet conclusive.
Map your everyday exposures in about ten minutes.
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Related factors
Including a factor does not mean it causes infertility: it is simply worth monitoring, depending on its level of evidence.
Content last updated: September 14, 2026